Muscle Physiology Research Laboratory

Welcome

Welcome to the Muscle Physiology Research Laboratory in the Department of Kinesiology and Community Health at the University of Illinois in Urbana-Champaign. Our lab conducts research on the cellular, molecular, and contractile adaptations of skeletal muscle to changes in mechanical signals (e.g. load), neural activity, or pro-inflammatory molecules. A major focus is studying the role of small heat shock proteins (HSP) in muscle adaptation utilizing various in vivo and in vitro models of increased loading such as muscle stretch and models of reduced muscle activation such as spinal cord injury. HSP proteins can assist in the maintenance of protein synthesis rates, refold damaged proteins, scavenge free radicals, and inhibit protein degradation which are all functions that may contribute to maintaining muscle integrity. We have investigated changes in the HSP expression in response to increased (functional overload) or decreased (denervation, spinal cord injury) muscle loading, in vivo.  Studies are also investigating how the HSPs may protect the muscle against the damaging loss of muscle mass associated with elevated levels of the pro-inflammatory cytokines, such as occurs with aging or disease.  We are also conducting research on how exercise training may increase HSP expression and consequently contribute to the anti-inflammatory effect of exercise.  Overall, our research has implications in several areas such as the benefits of exercise and training and the effects of aging and inactivity on our muscles.

In addition to supporting faculty led research projects, the Muscle Physiology Research Laboratory provides essential research opportunities for athletic training students in the undergraduate and graduate athletic training education programs at the University of Illinois at Urbana-Champaign. Laboratory experiences will expand a student’s theoretical understanding of the profession of Athletic Training, develop unique and innovative research skills, and foster intellectual growth through scholarly inquiry.

Dr. Kim Huey